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These oral symptoms can have a negative influence on functional outcome. Functional outcome after treatment for oral or oropharyngeal cancer is related to tumor site, tumor size, and the type of treatment received [4�C8]. A study in patients treated for cancer of the base of the tongue, found that surgery which included the mandible (mandibulectomy or mandibulotomy) reduced functional outcome significantly more than surgery which did not include the mandible [5]. In that study, functional outcome was assessed by eating, speech, and diet (eating in public and normalcy of diet). Furthermore, reconstruction with free-tissue transfer results in a significantly worse functional outcome when compared to direct reconstruction techniques [5, 6, 8]. Finally, a higher T stage (T3 or T4) and <a href="https://en.wikipedia.org/wiki/Succimer">Succimer</a> a <a href="https://www.selleckchem.com/products/AZD0530.html">AZD0530</a> larger resection size are also associated with a poorer functional outcome [4�C6, 8]. In addition to tumor and treatment characteristics, oral symptoms may also impede functional outcome. A restricted mouth opening affects mandibular function, including chewing, eating, and swallowing, and may also impede oral hygiene, dental treatment, and oncological follow-up [9]. Lack of saliva, resulting from radiation-induced damage to the salivary glands or from removal of a salivary gland, impedes consolidation of a food bolus and functional outcome significantly [10, 11]. Lack of retention and pain may inhibit biting and chewing in edentulous or partially dentate patients wearing a dental prosthesis [10]. Clinically, pain in the mouth can also impede functional outcome. To study oral symptoms related to oral and oropharyngeal cancer, and their association with functional outcome, three aims were formulated for this study. The first <a href="https://www.selleckchem.com/products/ldn193189.html">selleck products</a> was to assess oral symptoms of patients treated for oral or oropharyngeal cancer. Before treatment of oral or oropharyngeal cancer, most patients rank being cured as the most important outcome, followed by living as long as possible and having no pain. Only a few patients rank normal swallowing, normal taste, and normal salivation as important [12, 13]. It is currently unclear which oral symptoms are most burdensome to patients after treatment of oral and oropharyngeal cancer. The second aim was therefore to assess how patients rank the burden of their oral symptoms. Finally, oral or oropharyngeal cancer and the consequences of treatment can influence mandibular functioning (Fig.?1). However, it is unclear which factors have the largest impact on functional outcome.

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